An NIH-funded study, published in the journal Inflammation found that 2-HOBA supplementation affected the levels of 15 inflammatory biomarkers in healthy individuals, supporting the potential for 2-HOBA to benefit immune cells and promote a healthy balance of the immune system.
In this double-blind, randomized, and placebo-controlled study, researchers examined the potential beneficial effects of 2-HOBA on oxidative stress and inflammatory biomarkers in two cohorts of healthy younger and older adults.
Results indicated that 2-HOBA significantly increased levels of multiple protein biomarkers that play important roles in immune function regulation, including TNFβ, IL12β and CCL19, which contribute to immune system homeostasis or readiness. Furthermore, the study found that 2-HOBA decreased levels of TWEAK, a protein that promotes inflammation and cell death.
Even a healthy immune system involves inflammation. It is a part of the body’s repair process. But this response becomes detrimental when the body’s formation of reactive oxygen species (ROS) cascades out of control, resulting in the formation of reactive lipids.
When inflammation fails to resolve on its own, it can lead to the progression of harmful outcomes. But on the other hand, blocking the reactive compound formation that is associated with inflammation may have unintended consequences.
That’s why TSI Group has developed Hobamine. Hobamine is the patented ingredient scientifically known as 2-hydroxybenzylamine or 2-HOBA. Hobamine binds to pro-inflammatory reactive lipids, especially isolevuglandins (IsoLGs), one of the most common and reactive downstream products of oxidative stress, but without disrupting normal cell functions.