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A Proactive Approach to Aging

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We all want to live our best lives even as we age. 

In The Natural View podcast with Todd Pauli and Maggie Jaqua, they have special guest Shawn Baier, VP of Business Development at TSI Group, to discuss healthy aging, overlooked component, and nutritional ingredients to promote healthy aging.

Healthy, Active Aging

There are many various categories to focus on when we talk about healthy aging like joints, bones, and cognitive health.  One area that tends to get overlooked when it comes to healthy aging is muscle health.   

Unfortunately, we will all experience age-related muscle loss and if not addressed at all it can become a debilitating issue.  Our muscles carry out the physical demands of life and preventing muscle loss is easier than trying to restore lost muscle mass and strength.

Muscles Meet myHMB

The good news is there is an ingredient that is clinically proven to help prevent muscle loss – myHMB, scientifically known as beta-hydroxy beta-methylbutyrate or HMB. 

HMB in the past has been predominately known as a supplement for bodybuilders to help build muscle and improve recovery, but there is an array of research showing its potential in aging demographics to help prevent muscle loss during times of inactivity like bed rest after an illness or injury.   HMB can benefit any individual that wants to improve quality of life as we age.

Healthy Aging at a Cellular Level

We all experience oxidative stress in our lives, and while we can mitigate some of it, we cannot eliminate it.  Factors such environmental factors, lack of sleep, poor nutrition, alcohol, overexercising can all cause oxidative stress and when excessive oxidative stress happens it creates highly reactive molecules called free radicals and these can have a negative impact on the health of our cells and bodies.

A Radical Approach to Cellular Health

Hobamine, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound that is at the forefront of new developments to support cellular health, particularly as we age.

Hobamine (2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress.   This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell. 

Dive deeper into these topics by watching or listening to the full podcast on The Natural View!

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Hobamine – NutraIngredients USA Awards Winner!

dietary supplement bottle with Hobamine (2-HOBA) and a couple of pill capsules

TSI Group is proud to announce that 2023 Nutrition Research Project of the Year Award from NutraIngredients-USA goes to the NIH-funded Hobamine study.

NutraIngredients-USA Awards persist in acknowledging excellence within the dietary supplement industry.  With 17 different categories to enter, the awards honor the best and brightest ingredients, finished products, companies and people in the nutrition industry.

Hobamine’s Award Winning Study

The new NIH-funded study on Hobamine, Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans, received the Nutrition Research Project of the Year Award. 

This study showed the impact of 2-HOBA (Hobamine) supplementation on inflammatory biomarkers in healthy individuals and addressed the concern of maintaining a balanced immune system to prevent the progression of several diseases associated with chronic inflammation.  The findings of the study suggest that supplementing with 2 HOBA (Hobamine) can support a balanced immune system by enhancing inflammatory biomarkers in healthy individuals and reducing the levels of the protein TWEAK, which stimulates inflammation and tumor development.

“This interesting and well-designed study, funded by NIH, found that 2 HOBA (Hobamine) supplementation may promote a healthy balance of the immune system by improving inflammatory biomarkers in healthy individuals. Published in a peer review journal that indicates strong credibility, and it therefore provides opportunities for formulators and developers to add Hobamine, to their immune focused formulations, enabling healthy individuals to be more proactive about maintaining their immune readiness. The novelty of the ingredient and the impacts on inflammatory markers in healthy people really helped this project stand out,” stated Stephen Daniells, PhD, Editor-in-Chief of NutraIngredients-USA.

visual of clinical study Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans

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Ingredients for New Age Cellular Health

Author Mike Montemarano from Nutraceuticals World takes a look at ingredients that aim to extend health span from a cellular level.

Science continues to evolve on the human body and how there are key markers in human cells and DNA that can give us a better idea on the aging process.  With this new knowledge, many specialty ingredients are coming to the forefront to help try to set back our cellular clock.

Hallmarks of Biological Age

“Even though there is still no consensus about whether aging is biologically programmed, almost all gerontologists agree aging is a clinical disease responsible for the vast majority of deaths among the world’s populations,” said Marianne McDonagh, Vice President of Sales for Bioenergy Life Science, Inc.

Telomerase is an enzyme that plays a crucial role in the maintenance and protection of our DNA.  It is responsible for the extension and preservation of telomeres, which protect caps found at the ends of our chromosomes.  The production of telomerase declines with age, and the shortening of telomeres has been linked to various age-related diseases.

Another important process that has been linked to cellular health is the process of senescence.  This is where the cells are unable to continue to multiply even in optimal conditions.  This process increases with age and can cause cells to express pro-inflammatory cytokines and other toxins that impair tissue function. 

“All of these hallmarks represent a reason why the aging of our cells can affect our lives significantly.  With a longer lifespan, we don’t always experience a longer health span or high quality of life,” said Shawn Baier, Vice President of Business Development at TSI Group. “It is important to note that supplementation won’t completely reverse cellular aging, but it can address some of the negative effects connected to it.”

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 Emerging Ingredients

Researchers are looking at ingredients to address cellular health, specifically looks at two primary outcomes:

      • Inducing the death of senescent cells

      • Improving mechanical integrity of healthy cells

    TSI Group has recently launched the branded compound Hobamine (2-HOBA).  A recent NIH-funded study published in Inflammation showed that 2-HOBA was linked to positive changes in 15 inflammatory biomarkers in two small cohorts of younger and older adults.  This ingredient has the potential to ameliorate age-related declines in the immune system’s ability to self-limit its responses.  2-HOBA works as a scavenger of a pro-inflammatory reactive lipid called IsoLG.  This can help to prevent the body’s formation of reactive oxygen species (ROS) from cascading out of control.  As a result, ROS are neutralized before they react with DNA, proteins, and other components of the cell.

    To read more about this topic please follow the link below to the full article in Nutraceuticals World magazine.

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    New Study Shows 2-HOBA Supports Immune Function

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    NEW Study Shows 2-HOBA Supplementation has a Promising Impact on Immune Health.

    TSI Group is proud to announce positive results from a recent NIH-funded study on the impact of 2-hydroxybenzylamine (2-HOBA), TSI’s branded ingredient Hobamine, on inflammatory biomarkers.

    Balance is Essential to a Proactive Approach to Immune Health

    The NIH-funded study, published in the journal Inflammation, found that supplementing with 2-HOBA improved as many as 15 inflammatory biomarkers in healthy individuals, thereby promoting a healthy balance of the immune system.

    “Normally, inflammation is self-limiting, and its resolution is the first step in the repair and regeneration of injured tissues. Failure of inflammation resolution can lead to the progression of several diseases,” says John A. Rathmacher, Ph.D., Director of Clinical Research and Laboratory Services at MTI BioTech, Inc. That’s why a balanced immune system is incredibly important.

    Opportunities for Immune Formulations

    “These results enable us to enter a new space in immune health and will guide us in future research,” comments TSI Group Vice President of Business Development Shawn Baier, M.S., M.B.A. “More significantly, this opens opportunities for formulators and developers to add Hobamine to their immune formulas because it clearly enables healthy individuals to be more proactive about maintaining their immune readiness.”

    This concept of immune readiness is perhaps what Baier finds most exciting. “If you don’t have 2-HOBA present, and your body creates these highly-reactive, proinflammatory compounds, it could begin an unhealthy snowball effect. Having 2-HOBA on board means it’s ready and there when it’s needed. It supports your immune system’s ability to stay in balance, even when you are exposed to oxidative stressors.”

    Read the study or correlating articles below.

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    2-HOBA for Cellular Health

    wood table with 4 capsules containing brown powder inside and a white pill bottle subtle in the background

    TSI Group’s new compound, Hobamine (2-HOBA) has shown to support cellular health through a unique mechanism.

    As science continues to advance, looking at health at a cellular level has more prominant. 

    “Cellular health matters because it has an important impact on how well our bodies function, repair themselves, produce new body tissue, and much more,” according to Shawn Baier, vice president of business development with TSI Group’s Innovative Products Division. “As we all know, our immune system and how it responds to various stimuli has an effect on our cellular health, both positively and negatively. Cells form tissues, tissues form organs, and organs form systems that make up the body. Cellular health is the microscopic version of overall health—the healthier our cells, the healthier our body will be since our cells will be working optimally and efficiently with one another. “

    A Radical Approach to Cellular Health

    Oxidative stress is the primary cause of cellular damage. Excessive oxidative stress causes a buildup of a specific class of free radicals that can cause harm to the body.  Unfortunately, it’s merely impossible to eliminate all oxidative stress from our lives because of factors such as environment, poor nutrition, excess alcohol, lack of sleep, stress, and/or simply aging.

    Hobamine (2-HOBA), a bio-identical, chemically synthesized version of the naturally occurring compound 2-hydroxybenzylamine (2-HOBA) found in the buckwheat plant can help combat oxidative stress.  What makes Hobamine unique or even radical is that it works by acting specifically against compounds responsible for oxidative damage without blocking the processes needed for healthy cell function. 

    “Hobamine (2-HOBA) represents a paradigm shift in the approach to reducing the impact of oxidative stress because it is a selective scavenger of high-impact reactive oxygen species (ROS), specifically isolevuglandins (IsoLGs), but doesn’t interfere with or blunt fundamental physiological processes,” said Baier. “Therefore, 2-HOBA helps to return the healthy balance our cells and bodies need.”

    To read the full article feature in Nutraceuticals World please follow the link below.

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    abstract background depicting what healthy human cells would look like | Cellular Health | Hobamine (2-HOBA)

    Hobamine – A Breakthrough Hero

    Ingredient supplier TSI Group sits down with Nutritional Outlook to discuss how Hobamine (2-HOBA) is a “breakthrough” ingredient for cellular health.

    As an ingredient for healthy aging, Hobamine has a new unique method to combat oxidative stress without blocking normal physiological function and pathways.

    clear pill with digital background depicting innovative technologies in medicine systems, neural interfaces and research genetic and biology

    What exactly is Hobamine?

    Hobamine is a form of the naturally occurring compound 2-hydroxybenzylamine (2-HOBA).  Hobamine works by rapidly capturing specific reactive compounds formed by oxidative stress.   This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell. 

    Why Hobamine Over Antioxidants?

    Antioxidants may not be ideal because they block the development of oxidative stress altogether.  While that sounds like a good thing, our bodies need reactive oxygen species (ROS) which are created during the process of oxidative stress.  Our body needs normal levels of ROS because they are needed for cell signaling and immune system defense. 

    Instead of consuming high amounts of antioxidants, TSI proposes supplementing with Hobamine. 

    Hobamine – A Breakthrough Hero

    “The Hobamine story is about the villain versus the hero. The bad guy is what happens when everyday stress results in highly reactive free radical compounds. The hero, Hobamine, sweeps in to lock out the bad guys, creating a compound that is mere waste.” – Shawn Baier, MS, MBA, Vice President of Business Development at TSI Group

    TSI states that Hobamine is the only nutritional intervention on the market to address the negative impact of oxidative stress without blocking the body’s normal, healthy processes. 


    Please read the full article on Nutritional Outlook at the link below.


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    Hobamine – A Breakthrough Non-Antioxidant

    Hobamine (2-HOBA) has entered the spotlight as a new ingredient to help improve the balance of cellular health according to an article in Nutrition Insight.

    Hobamine is a patented ingredient from TSI Group that is a naturally occurring compound of hydroxybenzylamine (2-HOBA).  This ingredient is a breakthrough because it specifically targets the negative impact from oxidative stress without blunting the body’s normal and healthy processes. 

    Health at a Granular Level

    Cellular health is the foundation of overall health and becomes especially more important as we age. 

    “Cellular health matters because it has an important impact on how well the body functions, repairs itself, produces new body tissue and much more,” says principal investigator John A. Rathmacher, Ph.D. 

    We are made up of trillions of cells and those cells are the building blocks of the body.  Cell from tissues, tissues form organs, and organs form the systems that make up our bodies.  Everything that happens in our bodies starts on a cellular level.  In other words – the healthier our cells, the healthier our body will be. 

    More Than an Antioxidant

    Hobamine is notably not an antioxidant because it allows our bodies to continue their normal processes like cell signaling and immune function while minimizing the adverse effects of oxidative stress. 

    Whereas, antioxidants avoid the development of oxidative stress all together, but then this blocks our bodies from its normal physiological functions and pathways. 

    “Hobamine could easily become the next new vitamin C or vitamin D in terms of consumer acceptance,” comments VP of business development at TSI Group Shawn Baier. “It is a defender of every cell in the body.”

    To learn more please read the full article by Missy Green at the link below.

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    The Game Changer for Healthy Aging

    SRW Labs is changing the science of aging with their innovative cellular health supplements.

    For more than a decade the SRW team has been working in the biotechnology sector, focusing on the aging process at a cellular level. 


    Their work led to the nine identified, scientific hallmarks of aging.  This led to creating a supplement line tailored to benefiting health at a cellular level.


    A Game Changing Molecule

    In their development of this supplement line, one new ingredient that came to the forefront was Hobamine (2-HOBA).  This extract from Himalayan Tartary buckwheat has been found to help protect cells from damage caused from environment that leads to premature aging.


    Follow the link below for the full article in Alternative Medicine.

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    SRW Labs innovative cellular health prodducts Cel1 and Cel2 featuring the ingredient Hobamine (2-HOBA)

    SRW Labs Debuts Line of Products for Cellular Health

    SRW Labs new line of products features Hobamine, a new innovative ingredient tied to DNA protection and cellular health.

    SRW Laboratories led by founder Greg Macpherson has launched a line of products focused on cellular health supplements.  They pride themselves on utilizing innovative ingredients and work with a team of researchers to create unique products to promote health and wellness.

    The Discovery of Hobamine

    The novel ingredient Hobamine (scientifically known as 2-hydroxybenzlyamine; or 2-HOBA) was discovered by Vanderbilt University scientists through research spearheaded by Dr. Naji Abumrad, who is now a part of the SRW Advisory Board.

    In the early 2000s researchers at Vanderbilt developed 2-HOBA (Hobamine) and found it to be an effective ingredient to block the formation of IsoLG protein adducts in platelets and other cells.  What they found is that IsoLGs accumulate and can cause a variety of damage to the cell when there are too many of them.  What makes 2-HOBA (Hobamine) unique is its ability to act against compounds responsible for oxidative stress without blocking the processes needed for cell function.  This is an advanced approach to reducing the impact of oxidative stress.


    Follow the link below for the full article in Nutraceuticals World.

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